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Home > Products >  AP26113 Anti-cancer API

AP26113 Anti-cancer API CAS NO.1197953-54-0

  • Min.Order: 1 Gram
  • Payment Terms: T/T,
  • Product Details

Keywords

  • AP26113
  • Brigatinib
  • AP-26113

Quick Details

  • ProName: AP26113 Anti-cancer API
  • CasNo: 1197953-54-0
  • Molecular Formula: C29H39ClN7O2P
  • Appearance: white powder
  • Application: used by athletes to assist in training...
  • DeliveryTime: immediately
  • PackAge: aluminum foil bag
  • Port: HK, Shanghai, Shenzhen
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99%
  • Storage: cool and dry place
  • Transportation: EMS,DHL,HK post,EUB,ETK,NL post,German...
  • LimitNum: 1 Gram

Superiority

1.High Quality:
Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers throughout the world have very positive feedbacks towards our sarms. Purity is all guaranteed over 98%. HPLC and NMR is available if needed.
 
2.Reasonable price:
We provide high quality products with competitive price in China. All customers are welcomed to send us inquiries and get quotation.
 
3.Low MOQ:
No worry about the low MOQ, our MOQ is 1 gram or even lower.
 
4.Good Service. 
Fast response. We promise to reply within 24 hours including holidays and send quotation sheet and other documents within 48 hours.                                                                   
Before making orders, we do not cheat customers in order to get orders.
After selling, we promise to be reponsible and so not disappear if there is any complaint from customers on either our products or services.
 
5. Fast shipping and secure courier.
We promise to send out products and provide tracking number within 3 working days. And we send via different couriers based on different destination countries. We usually use NL post, HK post, Germany post, EUB, ETK, etc.
 
6.About resending or refunding if there is any loss of packages or failure to getting through custom.
We promise to resend up to half if it happens unluckily.

Details

Brigatinib potently inhibits the in vitro kinase activity of ALK (IC50, 0.6 nM) and all five mutant variants tested, including G1202R (IC50, 0.6-6.6 nM). Brigatinib demonstrates a high degree of selectivity, only inhibiting 11 additional native or mutant kinases with IC50 <10 nM. These include ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR (L858R; IC50, 1.5-2.1 nM). Brigatinib exhibits more modest activity against EGFR with a T790M resistance mutation (L858R/T790M), native EGFR, IGF1R, and INSR (IC50, 29-160 nM) and does not inhibit MET (IC50 >1000 nM). In cellular assays, brigatinib inhibits ALK and ROS1 with IC50s of 14 and 18 nM, respectively. Brigatinib inhibits FLT3 and IGF-1R with about 11-fold lower potency (IC50, 148-158 nM) and inhibits mutant variants of FLT3 and EGFR with 15- to 35-fold lower potency (IC50, 211-489 nM). Brigatinib inhibits cell growth with GI50 values ranging from 503 to 2,387 nM in three ALK-negative ALCL and NSCLC cell lines[1]. Brigatinib inhibits ALK activity and abrogates proliferation of ALK addicted neuroblastoma cell lines, with IC50 of 75.27 ± 8.89 nM. Brigatinib inhibits both the ALK-I1171N and the ALK-G1269A mutant receptors at 10 and 4 nM levels, respectively[3].

 

 

 

 

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