Benzbromarone CAS 3562-84-3 CAS NO.3562-84-3

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product Name: benzbromarone

Synonyms 3,5-dibromo-4-hydroxyphenyl-2-ethylbenzo[b]furan-3-yl ketoneMolecular 

Formula C17H12Br2O3

Molecular Weight 424.08

CAS Registry Number 3562-84-3

Quality: ministerial standard

EINECS 222-630-7

Benzbromarone is a uricosuric agent used in the treatment of gout and hyperuricemia. Studies show that use of Benzbromarone results in less complications than other uricosuric agent such as Allopurinol.

Function

Benzbromarone  is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is structurally related to the antiarrhythmic amiodarone.

Benzbromarone is highly effective and well tolerated, and clinical trials as early as 1981 and as recently as April 2008 have suggested it is superior to both allopurinol, a xanthine oxidase inhibitor but not uricosuric, andprobenecid, another uricosuric drug.

Application

Benzbromarone is a very potent inhibitor of CYP2C9. Several analogues of the drug have been developed as CYP2C9 and CYP2C19 inhibitors for use in research.