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Home > Products >  Supply 99% Afatinib/ BIBW 2992

Supply 99% Afatinib/ BIBW 2992 CAS NO.439081-18-2

  • Min.Order: 1 Gram
  • Payment Terms: T/T,
  • Product Details

Keywords

  • Afatinib
  • BIBW 2992
  • BIBW2992

Quick Details

  • ProName: Supply 99% Afatinib/ BIBW 2992
  • CasNo: 439081-18-2
  • Molecular Formula: C24H25N5O3FCl
  • Appearance: white powder
  • Application: used by athletes to assist in training...
  • DeliveryTime: immediately
  • PackAge: aluminum foil bag
  • Port: HK, Shanghai, Shenzhen
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99%
  • Storage: cool and dry place
  • Transportation: EMS,DHL,HK post,EUB,ETK,NL post,German...
  • LimitNum: 1 Gram

Superiority

1.High Quality:
Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers throughout the world have very positive feedbacks towards our sarms. Purity is all guaranteed over 98%. HPLC and NMR is available if needed.
 
2.Reasonable price:
We provide high quality products with competitive price in China. All customers are welcomed to send us inquiries and get quotation.
 
3.Low MOQ:
No worry about the low MOQ, our MOQ is 1 gram or even lower.
 
4.Good Service. 
Fast response. We promise to reply within 24 hours including holidays and send quotation sheet and other documents within 48 hours.                                                                   
Before making orders, we do not cheat customers in order to get orders.
After selling, we promise to be reponsible and so not disappear if there is any complaint from customers on either our products or services.
 
5. Fast shipping and secure courier.
We promise to send out products and provide tracking number within 3 working days. And we send via different couriers based on different destination countries. We usually use NL post, HK post, Germany post, EUB, ETK, etc.
 
6.About resending or refunding if there is any loss of packages or failure to getting through custom.
We promise to resend up to half if it happens unluckily.

Details

Afatinib is a new generation of oral small molecule tyrosine kinase inhibitor (TKI) and is the first irreversible ErbB family blocker that acts on the entire ErbB family, including EGFR. Unlike the first-generation reversible EGFR TKI, afatinib binds irreversibly to EGFR, thereby shutting down the cancer cell signaling pathway and inhibiting tumor growth.

 

Product name Afatinib (BIBW 2992)  Cas Number 39081-18-2
Moculer formula C24H25N5O3FCl Moculer weigh 485.944
 Appearance and traits white powder Density 1.380g/cm3
Melting point 100 - 102 °C Boiling point 676.917 at 760 mmHg
Flash point  363.186°C Refractive index 1.668

 

 

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively. Afatinib (BIBW 2992) is the second-generation potent and irreversible dual inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinase.

 

 

 

 

  1 Local advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) gene-sensitive mutations, previously untreated with EGFR tyrosine kinase inhibitor (TKI)
2 Local advanced or metastatic squamous type of non-small cell lung cancer (NSCLC) with or without disease progression during platinum chemotherapy.

 

 

 

 

 

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