Luteolin CAS NO.491-70-3

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【NAME】：Luteolin
【SYNONYMS】：Luteolol, Digitoflavone, 3',4',5,7-Tetrahydroxyflavone
【SPEC.】：98%
【TEST METHOD】： HPLC 
【PLANT SOURCE】：ResedaodorataL., Arachis hypogaea L.
【CAS NO.】：491-70-3
【MOLECULAR FORMULA & MOLECULAR Mass】：C15H10O6  286.24
【STRUCTURAL FORMULA】：                        
【CHARACTERISTIC】：Yellow crystalline powder，melting point is from 328 to 330℃。Soluble to 5 mM in 1eq. NaOH and to 50 mM in DMSO.
【PHARMACOLOGY】：Luteolin is a bioflavonel, considered to have bioactive effect on human health as antioxidant, radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, immunity system modulater. It is considered to play a role in prevention of cancer. Luteolin may possess pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. From preliminary research, the ability of luteolin to inhibit angiogenesis, to induce apoptosis, to affect carcinogenesis in animal models, to possibly reduce tumor growth in vivo, and to sensitize tumor cells to the cytotoxic effects of some anticancer drugs suggests that this flavonoid may have cancer chemopreventive and chemotherapeutic potential. Modulation of ROS levels, inhibition of topoisomerases I and II, reduction of NFkappaB and AP-1 activity, stabilization of p53, and inhibition of PI3K, STAT3, IGF1R, and HER2 are possible mechanisms involved in the putative biological activities of luteolin.
【CHEMICAL ANALYSIS 】